반응 #9474

반응 방정식

Triethylamine

7-bromo-4-chloro-3-nitroquinoline

1-Amino-2-methylpropan-2-ol

→

1-(7-bromo-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

수율 78.5%

용매

dichloromethane

반응 조건

후처리

1. 1
   온도to warm to ambient temperature
2. 2
   기타A precipitate formed
3. 3
   기타was isolated by filtration
4. 4
   세척washed with water
5. 5
   기타The crude solid was recrystallized from a mixture of isopropanol and acetonitrile

실험 절차

Triethylamine (17.35 mL, 124 mmol) was added to a solution of 7-bromo-4-chloro-3-nitroquinoline (29.84 g, 104 mmol) in dichloromethane (253 mL), and the reaction was cooled to 0° C. 1-Amino-2-methylpropan-2-ol (10.17 g, 114 mmol) was added dropwise, and then the reaction was allowed to warm to ambient temperature and stirred overnight. A precipitate formed and was isolated by filtration and washed with water. The crude solid was recrystallized from a mixture of isopropanol and acetonitrile to provide 27.78 g of 1-(7-bromo-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol as a solid.

출처