반응 #94718

반응 방정식

water

nopinone

pyrrolidine

p-toluenesulfonic acid

→

1-(6,6-dimethylnorpin-2-en-2-yl)-pyrrolidine

수율 95.0%

용매

benzene

반응 조건

후처리

1. 1
   온도at reflux for 40 h under nitrogen atmosphere in a vessel
2. 2
   기타After evaporation of the solvent and distillation of the residue

실험 절차

A solution of 30 g of nopinone ([α]D20 =+39.90; c=8 in ethanol), 29 of pyrrolidine and 0.4 g of p-toluenesulfonic acid in 150 ml anhydrous benzene was heated at reflux for 40 h under nitrogen atmosphere in a vessel fitted with a water separator. After evaporation of the solvent and distillation of the residue, there were obtained 39.5 g (95% yield) of 1-(6,6-dimethylnorpin-2-en-2-yl)-pyrrolidine having b.p. 117°-118° C./10 Torr.

출처