반응 #946923

반응 방정식

6-Methylpyridine-2-carbonitrile

methylhydrazine

methylhydrazine

→

N′,6-dimethylpyridine-2-carbohydrazonamide

수율 92.0%

용매

ethanol

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture was stirred for a further 16 h
2. 2
   기타The mixture was then evaporated

실험 절차

6-Methylpyridine-2-carbonitrile (45.3 g, 0.384 mol) and methylhydrazine (94 mL, 5.30 mol) were mixed with ethanol (200 mL). The mixture was stirred at room temperature overnight, and then an additional portion (18 mL, 1.00 mol) of methylhydrazine was added, and the mixture was stirred for a further 16 h. The mixture was then evaporated to give 58.0 g of crude N′,6-dimethylpyridine-2-carbohydrazonamide (˜92% yield), which was used for the next stage of the synthesis without additional purification.

출처