반응 #94692

반응 방정식

2-furyllithium

n-butyllithium

furan

4-chlorobutanol

5-chloropentanol

ammonium chloride

→

4-chloro-1-(2-furyl)-1-butanol

용매

ether

ether

hexane

반응 조건

후처리

1. 1
   세척The ether phase is washed with water and brine
2. 2
   건조dried over magnesium sulfate and potassium carbonate mixture
3. 3
   농축concentrated
4. 4
   기타to give a liquid

실험 절차

To a stirred suspension of 2-furyllithium (prepared from n-butyllithium and furan by the procedure of J. Org. Chem., 27, 1216 (1962) in ether and hexane at -78° C is added a solution of 4-chlorobutanol [Chem. Abstr., 59, 7579F (1963)] in of ether The mixture is warmed to 0° C and treated with saturated ammonium chloride. The ether phase is washed with water and brine, dried over magnesium sulfate and potassium carbonate mixture, and concentrated to give a liquid.

출처