반응 #94691

반응 방정식

ethyl mercaptoacetate

4-chloro-1-(2-furyl)-1-butanol

sodium ethoxide

→

4-(carbethoxymethylthio)-1-(2-furyl)-1-butanol

용매

ethanol

반응 조건

후처리

1. 1
   온도To a stirred, refluxing
2. 2
   온도at reflux for 3 hours
3. 3
   온도cooled
4. 4
   농축concentrated
5. 5
   기타to remove most of the ethanol
6. 6
   기타The residue is partitioned with ether and water
7. 7
   세척The ether phase is washed with brine
8. 8
   건조dried over potassium carbonate
9. 9
   농축The solution is concentrated
10. 10
    workup.ADDITIONdiluted with xylene
11. 11
    기타to give an oil

실험 절차

To a stirred, refluxing mixture of ethyl mercaptoacetate, and 4-chloro-1-(2-furyl)-1-butanol (Example 160), and sodium ethoxide in ethanol. The resulting mixture is stirred at reflux for 3 hours, cooled, and concentrated to remove most of the ethanol. The residue is partitioned with ether and water. The ether phase is washed with brine and dried over potassium carbonate. The solution is concentrated, diluted with xylene, and again conentrated to give an oil.

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