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8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

benzeneboronic acid

→

1-isobutyl-8-phenyl-1H-imidazo[4,5-c]quinolin-4-amine

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후처리

1. 1
   기타Recrystallization from isopropanol
2. 2
   기타followed by recrystallization from methanol

실험 절차

8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and benzeneboronic acid were coupled according to the general procedure described in Part J of Example 1. Recrystallization from isopropanol followed by recrystallization from methanol afforded 1-isobutyl-8-phenyl-1H-imidazo[4,5-c]quinolin-4-amine as a beige solid, m.p. 203–204° C.

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