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1-phenoxy-3-β-(2,5-dibenzyloxybenzamido)ethylamino-2-propanol

1-phenoxy-3-β-(3,4-dibenzyloxybenzamido)ethylamino-2-propanol

→

1-phenoxy-3-β-(2,5-dihydroxybenzamido)ethylamino-2-propanol

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실험 절차

The process described in Example 12 is repeated except that 1-phenoxy-3-β-(2,5-dibenzyloxybenzamido)ethylamino-2-propanol (oxalate m.p. 176°-178° C.; prepared as described in Example 1 from β-(2,5-dibenzyloxybenzamido)ethylamine, m.p. 96°-98° C.) or 1-phenoxy-3-β-(3,4-dibenzyloxybenzamido)ethylamino-2-propanol (Example 6) is used as starting material. There are thus obtained respectively 1-phenoxy-3-β-(2,5-dihydroxybenzamido)ethylamino-2-propanol (hemioxalate m.p. 195°-197° C. after crystallisation from a mixture of ethanol and water), and 1-phenoxy-3-β-(3,4-dihydroxybenzamido)-ethylamino-2-propanol, m.p. 178°-180° C. after crystallisation from ethanol.

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