반응 #94591

반응 방정식

ethyl 1-[N2 -(3-cyclohexyl-4-methoxyphenylsulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylate acetate

→

1-[N2 -(3-cyclohexyl-4-methoxyphenylsulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid

수율 73.4%

용매

chloroform

—

N-NaOH

ethanol

반응 조건

후처리

1. 1
   농축Then, the reaction mixture was concentrated
2. 2
   workup.DISSOLUTIONdissolved in 10 ml of water
3. 3
   기타to give a white gummy precipitate which
4. 4
   세척The chloroform solution was washed with saturated NaCl solution
5. 5
   건조dried over anhydrous sodium sulfate
6. 6
   기타evaporated in vacuo

실험 절차

A solution of 2.4 g of ethyl 1-[N2 -(3-cyclohexyl-4-methoxyphenylsulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylate acetate in 10 ml of ethanol and 10 ml of N-NaOH solution was stirred overnight at room temperature. Then, the reaction mixture was concentrated and dissolved in 10 ml of water. The solution was neutralized with 2N-HCl solution to give a white gummy precipitate which was dissolved in 150 ml of chloroform. The chloroform solution was washed with saturated NaCl solution, dried over anhydrous sodium sulfate and evaporated in vacuo to give 1.52 g of 1-[N2 -(3-cyclohexyl-4-methoxyphenylsulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid as an amorphous solid. I.R. (KBr): 3350, 2920, 1620, 1250 cm-1.

출처