반응 #9457

반응 방정식

7-phenylquinolin-4-ol

Nitric acid

→

3-nitro-7-phenylquinolin-4-ol

수율 81.4%

용매

propionic acid

반응 조건

후처리

1. 1
   workup.ADDITIONdropped to 124° C
2. 2
   온도cooled to 5° C. on an ice bath
3. 3
   여과The resulting solid was collected by filtration
4. 4
   세척washed with ice cold ethanol (until washings
5. 5
   기타dried at 70° C. in a vacuum oven overnight

실험 절차

A stirred suspension of 7-phenylquinolin-4-ol (84.9 g, 384 mmol) in propionic acid (850 mL) was heated to 129° C. Nitric acid (70%, 45.0 g) was added dropwise over 25 min, during which the temperature dropped to 124° C. The reaction was stirred an additional 3 h at that temperature and then cooled to 5° C. on an ice bath. The resulting solid was collected by filtration, washed with ice cold ethanol (until washings were nearly colorless) and dried at 70° C. in a vacuum oven overnight to obtain 83.2 g of 3-nitro-7-phenylquinolin-4-ol as a beige powder.

출처