반응 #94555

반응 방정식

1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane

sodium carbonate

p-chlorobenzoyl chloride

→

3-p-chlorobenzoyl-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane

용매

benzene

반응 조건

후처리

1. 1
   기타The benzene is evaporated
2. 2
   workup.DISSOLUTIONthe dark purple residue is dissolved in 200 ml of chloroform
3. 3
   세척washed successively with 5% sodium carbonate, 0.5N hydrochloric acid
4. 4
   건조with water and dried over sodium sulfate giving a dark purple oil
5. 5
   workup.ADDITIONAddition of ether

실험 절차

A 19.35 g sample of 1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane, 10.59 g of sodium carbonate and 17.5 g of p-chlorobenzoyl chloride are reacted in benzene. The benzene is evaporated and the dark purple residue is dissolved in 200 ml of chloroform and washed successively with 5% sodium carbonate, 0.5N hydrochloric acid and then with water and dried over sodium sulfate giving a dark purple oil. Addition of ether gives the product 3-p-chlorobenzoyl-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane as grey crystals, mp 98°-100° C.

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