반응 #945
ord-968da5d345074707bd8ae7f036b4987e
반응 방정식
benzaldehyde
product
Ethyl 2-aminobutyrate hydrochloride
magnesium sulphate
triethylamine
→
desired product
수율 88.9%
Ethyl 2-benzylideneaminobutyrate
수율 88.9%
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과then filtered
- 2농축The filtrate was concentrated
- 3기타triturated in diethyl ether
- 4여과filtered
- 5농축concentrated
실험 절차
A solution of the product from step (a) (149.6 g), magnesium sulphate (74.3 g), and triethylamine (246 ml) in dichloromethane (1500 ml) was stirred at room temperature under nitrogen and benzaldehyde (94.9 g, Aldrich) was added dropwise. The mixture was stirred at room temperature for 3 hours then filtered. The filtrate was concentrated, triturated in diethyl ether, filtered and concentrated to yield the desired product as a yellow oil (174 g). 1H NMR consistent with the proposed structure.