반응 #9447

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7-Bromo-2-butyl-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

benzeneboronic acid

→

2-butyl-1-isobutyl-7-phenyl-1H-imidazo[4,5-c]quinolin-4-amine

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후처리

1. 1
   기타Purification by chromatography on silica gel (20% acetone in toluene to 60% acetone in toluene gradient)

실험 절차

7-Bromo-2-butyl-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and benzeneboronic acid were coupled according to the general procedure described in Part J of Example 1. Purification by chromatography on silica gel (20% acetone in toluene to 60% acetone in toluene gradient) afforded 2-butyl-1-isobutyl-7-phenyl-1H-imidazo[4,5-c]quinolin-4-amine as a white solid, m.p. >250° C.

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