반응 #944608

ord-5caa6a058f1d4e80a52af1b256684402

반응 방정식

OB(O)c1cccc(-c2ccccc2)c1
1,1′-biphenyl-3-ylboronic acid
CC(C(=O)[O-])C1CCn2c1c(Br)c1c(S(C)(=O)=O)cc(F)cc12
(+/−)-methyl[9-bromo-6-fluoro-8-(methylsulfonyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate
→
CS(=O)(=O)c1cc(F)cc2c1c(-c1cccc(-c3ccccc3)c1)c1n2CCC1CC(=O)O
title compound
CS(=O)(=O)c1cc(F)cc2c1c(-c1cccc(-c3ccccc3)c1)c1n2CCC1CC(=O)O
(+/−)-[9-(1,1′-BIPHENYL-3-YL)-6-FLUORO-8-(METHYLSULFONYL)-2,3-DIHYDRO-1H-PYRROLO[1,2-a]INDOL-1-YL]ACETIC ACID

반응물

OB(O)c1cccc(-c2ccccc2)c1
1,1′-biphenyl-3-ylboronic acid
CC(C(=O)[O-])C1CCn2c1c(Br)c1c(S(C)(=O)=O)cc(F)cc12
(+/−)-methyl[9-bromo-6-fluoro-8-(methylsulfonyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Starting from 1,1′-biphenyl-3-ylboronic acid and (+/−)-methyl[9-bromo-6-fluoro-8-(methylsulfonyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl]acetate (Example 126, Step 1), the title compound was synthesized following the procedures described in Step 2 of Example 126 and Step 10 of Example 7.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07144913B2uspto-grants-2006_12