반응 #9445

반응 방정식

Na2S2O4

(7-bromo-3-nitroquinolin-4-yl)isobutylamine

→

7-bromo-N4-isobutylquinoline-3,4-diamine

수율 135.6%

용매

H2O

isopropanol

반응 조건

후처리

1. 1
   workup.ADDITIONUpon complete addition
2. 2
   기타the bulk of the isopropanol was removed on a rotary evaporator
3. 3
   추출The resulting mixture was extracted with CH2Cl2 (3×)
4. 4
   건조the combined organic layers were dried over Na2SO4
5. 5
   여과filtered
6. 6
   농축concentrated

실험 절차

A solution of Na2S2O4 (193 g) in H2O (1 L) was added to a boiling solution of (7-bromo-3-nitroquinolin-4-yl)isobutylamine (32.0 g, 99 mmol) in isopropanol (1 L). Upon complete addition, the reaction mixture was cooled to room temperature and the bulk of the isopropanol was removed on a rotary evaporator. The resulting mixture was extracted with CH2Cl2 (3×), and the combined organic layers were dried over Na2SO4, filtered, and concentrated to afford 39.5 g of the crude 7-bromo-N4-isobutylquinoline-3,4-diamine as a yellow solid.

출처