반응 #943989

반응 방정식

water

7-hydroxy-6-methoxy-1-tetralone

benzyl bromide

K2CO3

→

product

수율 62.8%

7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one

수율 62.8%

용매

acetone

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도to reflux overnight
3. 3
   기타The reaction
4. 4
   온도as cooled
5. 5
   추출extracted with EtOAc
6. 6
   건조The EtOAc was dried over Na2SO4
7. 7
   기타evaporated
8. 8
   기타to give 7 g of crude product
9. 9
   기타Crystallization with Et2O

실험 절차

A mixture of 4.5 g (0.0233 mole) of 7-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.032 mole) of benzyl bromide and 10 g (0.072 mole) of K2CO3 in 150 ml of acetone was heated to reflux overnight. The reaction as cooled, poured into water and extracted with EtOAc. The EtOAc was dried over Na2SO4 and evaporated to give 7 g of crude product. Crystallization with Et2O gave 4.13 g of product as a white solid, mp 110-111° C.

출처