반응 #94285
ord-afaf807a19e14d4ba6b67437a2a92448
반응 방정식
2-chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydropyrido(2,3-d)pyrimidine
1-propyl-piperazine
→
2-(4'-propylpiperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine
수율 84.6%
반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
As described in Example XII, the condensation of 2.8 g of 2-chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydropyrido(2,3-d)pyrimidine with 2.2 g of 1-propyl-piperazine, in chloroform (40 cm3) gives, after the treatments described in Example XII, 3.14 g of 2-(4'-propylpiperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine (yield 84%); melting point 149° C., after recrystallisation from ethyl acetate.