반응 #94284

반응 방정식

2-chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine

1-ethylpiperazine

→

2-(4'-ethylpiperazino)-5-oxo-8-ethyl-6-carbethoxy-5,8-dihydro-pyrido(2,3-d)pyrimidine

수율 93.0%

용매

chloroform

반응 조건

후처리

1. 1
   온도are heated
2. 2
   온도under reflux for 2 hours
3. 3
   온도After cooling
4. 4
   세척the organic solution is washed with water
5. 5
   건조dried over MgSO4
6. 6
   기타the solvent is evaporated
7. 7
   기타the residue is recrystallised from a mixture of isopropyl ether (15 cm3) and benzene (25 cm3)

실험 절차

3.8 g of 2-chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine and 2.9 g of 1-ethylpiperazine, dissolved in 50 cm3 of chloroform, are heated under reflux for 2 hours. After cooling, the organic solution is washed with water and dried over MgSO4 ; the solvent is evaporated and the residue is recrystallised from a mixture of isopropyl ether (15 cm3) and benzene (25 cm3) and gives 4.4 g (yield: 93%) of 2-(4'-ethylpiperazino)-5-oxo-8-ethyl-6-carbethoxy-5,8-dihydro-pyrido(2,3-d)pyrimidine; melting point 161° C.

출처