반응 #94247

반응 방정식

4-hydroxy-4-phenylpiperidine

ethyl trifluoroacetate

→

1-trifluoroacetyl-4-hydroxy-4-phenylpiperidine

반응 조건

후처리

1. 1
   기타The starting material is prepared
2. 2
   온도is refluxed overnight
3. 3
   기타evaporated
4. 4
   세척the solution washed with 1N hydrochloric acid
5. 5
   기타dried
6. 6
   기타evaporated
7. 7
   기타The residue is recrystallized from ethyl acetate-petroleum ether

실험 절차

The starting material is prepared as follows: The mixture of 25 g of 4-hydroxy-4-phenylpiperidine and 50 ml of ethyl trifluoroacetate is refluxed overnight and evaporated. The residue is taken up in benzene, the solution washed with 1N hydrochloric acid, dried and evaporated. The residue is recrystallized from ethyl acetate-petroleum ether, to yield the 1-trifluoroacetyl-4-hydroxy-4-phenylpiperidine melting at 123°-125°.

출처