반응 #94242

반응 방정식

4-hydroxy-4-phenylpiperidine hydrochloride

acetone

paraformaldehyde

nitromethane

→

4-(4-hydroxy-4-phenypiperidino)-2-butanone hydrochloride

용매

cyclohexane

반응 조건

후처리

1. 1
   기타The starting material is prepared
2. 2
   기타the precipitate collected

실험 절차

The starting material is prepared as follows: The solution of 20 g of 4-hydroxy-4-phenylpiperidine hydrochloride, 10 ml of acetone, 5.6 g of paraformaldehyde and 100 ml of nitromethane is refluxed for 12 hours. It is diluted with 500 ml of cyclohexane and the precipitate collected, to yield the 4-(4-hydroxy-4-phenypiperidino)-2-butanone hydrochloride.

출처