반응 #94238

반응 방정식

4-hydroxy-4-phenylpiperidine

carbon dioxide

2-(1,4-benzodioxan-2-yl)-acetic acid

→

1-[2-(1,4-benzodioxan-2-yl)-acetyl]-4-hydroxy-4-phenylpiperidine

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타It is evaporated
2. 2
   세척the solution washed with water, N hydrochloric acid and water
3. 3
   기타dried
4. 4
   기타evaporated

실험 절차

To the stirred solution of 11.64 g of 2-(1,4-benzodioxan-2-yl)-acetic acid in 60 ml of tetrahydrofuran is added 12 g of 1,1-carbonyldiimidazole. After the evolution of carbon dioxide has ceased, 10.6 g of 4-hydroxy-4-phenylpiperidine are added and the mixture stirred overnight at room temperature. It is evaporated, the residue taken up in ethyl acetate, the solution washed with water, N hydrochloric acid and water, dried and evaporated, to yield the 1-[2-(1,4-benzodioxan-2-yl)-acetyl]-4-hydroxy-4-phenylpiperidine.

출처