반응 #94232

반응 방정식

2-(2-tosyloxyethyl)-1,4-benzodioxan

4-hydroxy-4-phenylpiperidine

sodium carbonate

→

2-[2-(4-hydroxy-4-phenylpiperidino)-ethyl]-1,4-benzodioxan

용매

4-methyl-2-pentanone

반응 조건

후처리

1. 1
   온도is refluxed 48 hours
2. 2
   여과It is filtered
3. 3
   기타evaporated
4. 4
   기타the residue recrystallized from isopropanol

실험 절차

The mixture of 6.68 g of 2-(2-tosyloxyethyl)-1,4-benzodioxan, 3.54 g of 4-hydroxy-4-phenylpiperidine, 10 g of anhydrous sodium carbonate and 100 ml of 4-methyl-2-pentanone is refluxed 48 hours. It is filtered, evaporated and the residue recrystallized from isopropanol, to yield the 2-[2-(4-hydroxy-4-phenylpiperidino)-ethyl]-1,4-benzodioxan melting at 142°.

출처