반응 #9419

반응 방정식

sodium carbonate

3,3-dimethyl-indol-2-one

sodium acetate

bromine

→

subtitled compound

수율 92.0%

5-bromo-1,3-dihydro-3,3-dimethyl-2H-indol-2-one

수율 92.0%

용매

acetic acid

water

acetic acid

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate (×3)
2. 2
   건조dried (MgSO4)
3. 3
   여과filtered
4. 4
   기타evaporated

실험 절차

3,3-dimethyl-indol-2-one (0.65 g, 4.03 mmol) and sodium acetate (0.33 g, 4.07 mmol) were stirred in acetic acid (5 cm3) then bromine (0.66 g, 4.13 mmol) in acetic acid (5 cm3) was added drop-wise to the reaction mixture. The reaction was stirred for 50 min., then poured into water. The mixture was basified with sodium carbonate, extracted with ethyl acetate (×3), dried (MgSO4), filtered, and evaporated to give the subtitled compound (0.89 g, 92%) 1H NMR (DMSO-d6) δ 1.21 (s, 6 H), 6.76 (d, 1 H, J=8.22 Hz), 7.29 (dd, 1 H, J=2.12 Hz, 8.23 Hz), 7.49 (d, 1 H, J=2.03 Hz), 10.4 (s, 1H).

출처