반응 #94150

반응 방정식

L-proline tert-butyl ester

3-hydroxybenzotriazole

dicyclohexylcarbodiimide

3-acetylthio-2-methoxycarbonylmethylpropanoic acid

→

1-[3-(acetylthio)-2-methoxycarbonylmethylpropanoyl]-L-proline tert-butyl ester

수율 99.2%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타the precipitate formed
2. 2
   여과is filtered off
3. 3
   세척the filtrate is washed neutral
4. 4
   기타dried
5. 5
   농축concentrated to dryness

실험 절차

To a solution of L-proline tert-butyl ester (1.71 g) and 3-hydroxybenzotriazole (1.35 g) in dichloromethane (15 ml), dicyclohexylcarbodiimide (2.06 g) and 3-acetylthio-2-methoxycarbonylmethylpropanoic acid (2.2 g) are added. After 18 hours stirring at room temperature, the precipitate formed is filtered off, the filtrate is washed neutral, dried, and concentrated to dryness to yield 3.7 g of 1-[3-(acetylthio)-2-methoxycarbonylmethylpropanoyl]-L-proline tert-butyl ester. Rf =0.8 (silica gel-etyl acetate).

출처