반응 #9410

반응 방정식

oxime

3-fluoro-5-bromobenzaldehyde oxime

→

3-fluoro-5-bromobenzonitrile

수율 89.3%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도under reflux
3. 3
   기타the mixture was evaporated
4. 4
   세척washed with sulfuric acid (1N), water, brine
5. 5
   건조dried (MgSO4)
6. 6
   기타evaporated

실험 절차

The above oxime (3.76 g, 17.24 mmol) and copper (II) acetate (370 mg) were dissolved in acetonitrile (100 cm3) under nitrogen and heated under reflux. After 5 h, the mixture was evaporated, the residue taken into EtOAc, washed with sulfuric acid (1N), water, brine, dried (MgSO4) and evaporated to give 3-fluoro-5-bromobenzonitrile (3.08 g, 15.39 mmol, 89%) which was used without further purification.

출처