반응 #94097

반응 방정식

4-(4-methylphenethyloxy)phenyl isocyanate

N,O-dimethylhydroxylamine

→

N'-[4-(4-methylphenethyloxy)phenyl]-N-methoxy-N-methylurea

수율 108.4%

용매

benzene

benzene

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the addition
2. 2
   기타Thereafter, the solvent is removed under reduced pressure
3. 3
   기타the residue is recrystallized from ethanol

실험 절차

Into a solution of 5.5 g of 4-(4-methylphenethyloxy)phenyl isocyanate in 100 ml of benzene, a solution of 2 g of N,O-dimethylhydroxylamine in 50 ml of benzene is added dropwise at 20° to 30° C. After the addition is finished, the reaction mixture is continuously stirred at the same temperature for an additional 30 minutes. Thereafter, the solvent is removed under reduced pressure, and the residue is recrystallized from ethanol to obtain 7.4 g of N'-[4-(4-methylphenethyloxy)phenyl]-N-methoxy-N-methylurea as white needles, M.P. 82°-83° C.

출처