반응 #94080

반응 방정식

diethyl ketone

isopropanol

sodium hydroxide

β-hydroxybutyraldehyde

diethyl ketone

→

2,5,6-trimethyl-2-cyclohexen-1-one

수율 47.1%

용매

acetic acid

반응 조건

후처리

1. 1
   온도under reflux
2. 2
   workup.WAITThe whole is boiled for another hour
3. 3
   온도under reflux
4. 4
   기타the aqueous phase is separated

실험 절차

A mixture of 88 g of β-hydroxybutyraldehyde and 150 g of diethyl ketone is added dropwise in the course of one hour to a mixture of 250 g of diethyl ketone, 80 g of isopropanol and 5 g of sodium hydroxide powder which is boiling under reflux. The whole is boiled for another hour under reflux. Neutralization is effected with glacial acetic acid and the aqueous phase is separated. The organic layer is fractionated. 65 g of 2,5,6-trimethyl-2-cyclohexen-1-one having a boiling point of 74° to 76° C. at 12 mm Hg is obtained. The yield is 47% with reference to β-hydroxybutyraldehyde.

출처