반응 #94034

반응 방정식

2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine

N-cyano-N'-(2-methoxyethyl)-carbamimidothioic acid, methyl ester

→

N-cyano-N'-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N"-(2-methoxyethyl)guanidine

수율 41.3%

반응 조건

후처리

1. 1
   온도was heated on a steam bath for 6.5 hr
2. 2
   기타to remove methanethiol
3. 3
   기타The crude product was purified by chromatography (silica gel/methanol)

실험 절차

A mixture of 2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine (2.14 g) and N-cyano-N'-(2-methoxyethyl)-carbamimidothioic acid, methyl ester (1.73 g) was heated on a steam bath for 6.5 hr. Vacuum was applied occasionally to remove methanethiol. The crude product was purified by chromatography (silica gel/methanol) to give N-cyano-N'-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N"-(2-methoxyethyl)guanidine (1.4 g). Analysis Found: C, 50.51; H, 7.20; N, 19.41, C15H25N5O2S.H2O requires: C, 50.42; H, 7.50; N, 19.60%.

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