반응 #94017

반응 방정식

5-(Dimethylamino)methyl-2-furanmethanol

cysteamine hydrochloride

sodium carbonate

→

2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine

수율 54.2%

용매

hydrochloric acid

반응 조건

후처리

1. 1
   추출the resultant solid extracted with diethyl ether
2. 2
   기타Removal of solvent
3. 3
   workup.DISTILLATIONfollowed by distillation of the residue

실험 절차

5-(Dimethylamino)methyl-2-furanmethanol (15.5 g) was added dropwise to a stirred, ice-cold solution of cysteamine hydrochloride (11.36 g) in concentrated hydrochloric acid (40 ml). After standing at 0° for 18 hr, excess anhydrous sodium carbonate was added and the resultant solid extracted with diethyl ether. Removal of solvent followed by distillation of the residue gave 2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine (11.6 g) b.p. 104-106° (0.1 mm). Picrate salt m.p. 142-144°.

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