반응 #94014

반응 방정식

2-furanmethanol

methylamine hydrochloride

sodium carbonate

→

5-(methylamino)methyl-2-furanmethanol

용매

formaldehyde

반응 조건

후처리

1. 1
   workup.WAITto stand for 16 hr
2. 2
   추출the slurry extracted with ethyl acetate
3. 3
   기타After removal of solvent the residue
4. 4
   workup.DISTILLATIONwas distilled

실험 절차

A mixture of 2-furanmethanol (49 g), methylamine hydrochloride (51.5 g) and 36% formaldehyde solution (50 ml) was stirred at 0°-3° for 3 hr and allowed to stand for 16 hr. Excess sodium carbonate was added and the slurry extracted with ethyl acetate. After removal of solvent the residue was distilled to give 5-(methylamino)methyl-2-furanmethanol (36.2 g) b.p. 111°-113° (0.2 mm).

출처