반응 #939930

반응 방정식

Phosphorus trichloride

cyclopentanecarboxylic acid

bromine

→

title compound

1-Bromocyclopentanecarboxylic acid

반응 조건

후처리

1. 1
   온도After cooling to ambient temperature
2. 2
   기타the mixture was partitioned between EtOAc and water
3. 3
   기타The organic portion was separated
4. 4
   세척washed with water and brine

실험 절차

Phosphorus trichloride (0.54 mL, 6.20 mmol) was added drop-wise to the mixture of cyclopentanecarboxylic acid (14.2 g, 124 mmol) and bromine (7.35 mL, 143 mmol). The mixture was then gradually heated to 85° C. and stirred at this temperature in a sealed vessel for 12 h. After cooling to ambient temperature, the mixture was partitioned between EtOAc and water. The organic portion was separated, washed with water and brine, and conc. in vacuo to give the title compound as a white solid.

출처