반응 #93991

반응 방정식

1-(2-Ethoxycarbonylpropanoyl)-L-proline

→

1-(2-carboxypropanoyl)-L-proline

용매

sodium hydroxide

methanol

반응 조건

후처리

1. 1
   농축concentrated to half volume in vacuo
2. 2
   workup.ADDITIONIon exchange resin (Dowex 50) (50 ml.) is added
3. 3
   workup.ADDITIONThe fractions containing the desired material (carboxyl reagent positive)
4. 4
   기타freeze dried
5. 5
   기타to obtain

실험 절차

1-(2-Ethoxycarbonylpropanoyl)-L-proline (4.1 g.) is dissolved in a mixture of N sodium hydroxide (51 ml.) and methanol (51 ml.). The solution is kept at room temperature for 6 hours and then concentrated to half volume in vacuo. Ion exchange resin (Dowex 50) (50 ml.) is added and the suspension applied to a column of 150 ml. of the same resin. The fractions containing the desired material (carboxyl reagent positive) are pooled and freeze dried to obtain to obtain 1-(2-carboxypropanoyl)-L-proline, yield 1.5 g.

출처