반응 #93946

반응 방정식

4-[(4,5-dihydro-2-thiazolyl)amino]-tetrahydro-3,5-bis[(4-methoxyphenyl)methylene]thiopyran-4-ol-1,1-dioxide

→

2,3,8,9-Tetrahydro-5-(4-methoxyphenyl)-9-[(4-methoxyphenyl)methylene]-5H,6H-thiazolo[3,2-a]thiopyrano[4,3-d]pyrimidine-7,7-dioxide

용매

n-BuOH

DMSO

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도at reflux for 1 hour
3. 3
   온도After cooling
4. 4
   기타Crystallization from 25 ml of DMF
5. 5
   기타gives 4.0 g (69%) of cream colored product, m.p. 243°-245°

실험 절차

A suspension of 4-[(4,5-dihydro-2-thiazolyl)amino]-tetrahydro-3,5-bis[(4-methoxyphenyl)methylene]thiopyran-4-ol-1,1-dioxide (6.0 g, 0.012 mole) in 75 ml of n-BuOH and 25 ml of DMSO is stirred and heated at reflux for 1 hour. The volume of the resulting solution is reduced by approximately one-half using a Dean-Stark trap. After cooling, the yield of yellow product is 4.7 g, m.p. 235°-240°. Crystallization from 25 ml of DMF gives 4.0 g (69%) of cream colored product, m.p. 243°-245°.

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