반응 #939018

반응 방정식

sulfuric acid

butyl iodide

iodine

adipic acid monoethyl ester chloride

→

Ethyl 6-Oxodecanoate

용매

water

toluene

butyl acetate

반응 조건

후처리

1. 1
   기타to react
2. 2
   workup.ADDITIONwas added to the reaction solution
3. 3
   추출The oily layer was extracted with ether
4. 4
   세척washed with aqueous sodium hydrogencarbonate
5. 5
   세척washed with water
6. 6
   기타dried
7. 7
   기타The residue was evaporated
8. 8
   기타to remove the solvent
9. 9
   workup.DISTILLATIONdistilled

실험 절차

A mixture of activated zinc-copper catalyst (11.5 g), butyl acetate (4 g), toluene (5 g), butyl iodide (15 g) and iodine (3 mg) was heated at 110-120° C. for 2 hours. The mixture was then added dropwise with adipic acid monoethyl ester chloride(15.7 g) at 0° C., and then was allowed to react. After the reaction was completed, ice-cooled water was added to the reaction solution, and then decomposed with dilute sulfuric acid. The oily layer was extracted with ether, washed with aqueous sodium hydrogencarbonate, washed with water, and then dried. The residue was evaporated to remove the solvent, and then distilled, thereby giving ethyl 6-oxodecanoate (8.1 g).

출처