반응 #93855

반응 방정식

2,2-dimethyl-1-ethinyl-7-methoxy-3-(N-methyl-p-toluenesulphonamido)-1,2,3,4-tetrahydro-1-naphthol

→

2,2-Dimethyl-7-methoxy-3-(N-methyl-p-toluenesulphonamido)-1,2,3,4-tetrahydro-1-vinyl-1-naphthol

수율 95.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타is submitted to hydrogenation at atmospheric pressure and room temperature
2. 2
   기타After the absorption of 1200 ml of hydrogen the catalysts
3. 3
   기타are removed by filtration
4. 4
   농축The solution is concentrated by evaporation in vacuo of most of the solvent
5. 5
   기타whereafter the product crystallizes as white crystals melting at 152°-154° C

실험 절차

A mixture of 205 g of 2,2-dimethyl-1-ethinyl-7-methoxy-3-(N-methyl-p-toluenesulphonamido)-1,2,3,4-tetrahydro-1-naphthol, 0.8 g of 0,5% palladium on calcium carbonate, 0.8 g 5% palladium on charcoal and 1000 ml of ethyl acetate is submitted to hydrogenation at atmospheric pressure and room temperature. After the absorption of 1200 ml of hydrogen the catalysts are removed by filtration. The solution is concentrated by evaporation in vacuo of most of the solvent, whereafter the product crystallizes as white crystals melting at 152°-154° C. Yield 95%.

출처