반응 #937308

반응 방정식

2-bromoindene

propylmagnesium chloride

→

desired product

수율 99.8%

2-Propylindene

수율 99.8%

반응 조건

후처리

1. 1
   workup.ADDITIONTo an oven-dried 250 mL round bottom flask containing a magnetic stir bar
2. 2
   기타equipped with a reflux condenser
3. 3
   기타evacuated
4. 4
   workup.ADDITIONDeoxygenated anhydrous diethyl ether (150 mL) was added via cannula under argon at -78° C
5. 5
   온도without exterior cooling as 42 mL of a 2.0 M propylmagnesium chloride in ether solution
6. 6
   기타The reaction was placed in a dry ice/acetone bath
7. 7
   온도when a vigorous reflux
8. 8
   기타The dry ice/acetone bath was removed after 2 minutes
9. 9
   workup.STIRRINGthe reaction was stirred at room temperature under argon for 90 minutes
10. 10
    workup.ADDITIONThe reaction was carefully poured into water and 10 weight percent aqueous HCl
11. 11
    workup.ADDITIONwas added until the mixture
12. 12
    추출The mixture was extracted with ether (3×200 mL)
13. 13
    세척the combined organic layers were washed with water (1×250 mL), with aqueous sodium bicarbonate (1×250 mL)
14. 14
    건조Drying over anhydrous sodium sulfate
15. 15
    여과followed by filtration and solvent removal

실험 절차

To an oven-dried 250 mL round bottom flask containing a magnetic stir bar and equipped with a reflux condenser and vacuum adapter was added 2-bromoindene (15.0 g, 76.9 mmol) and Ni(dppp)Cl2 (0.42 g, 0.77 mmol) (dppp=1,3-bis(diphenyl-phosphino)propane). The flask was stoppered and evacuated. Deoxygenated anhydrous diethyl ether (150 mL) was added via cannula under argon at -78° C. The reaction was stirred under argon without exterior cooling as 42 mL of a 2.0 M propylmagnesium chloride in ether solution was added via syringe (84 mmol propylmagnesium chloride). The reaction was placed in a dry ice/acetone bath when a vigorous reflux was achieved. The dry ice/acetone bath was removed after 2 minutes, and the reaction was stirred at room temperature under argon for 90 minutes. The reaction was carefully poured into water and 10 weight percent aqueous HCl was added until the mixture was acidic. The mixture was extracted with ether (3×200 mL), and the combined organic layers were washed with water (1×250 mL), with aqueous sodium bicarbonate (1×250 mL), and with aqueous saturated sodium chloride solution (1×250 mL). Drying over anhydrous sodium sulfate followed by filtration and solvent removal yielded 12.14 g (99.7 percent) of the desired product.

출처