반응 #93668

반응 방정식

2-bromopropionyl bromide

triethylamine

2-benzylthioethanol

→

2-benzylthioethyl 2-bromopropionate

용매

toluene

toluene

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGthe reaction mixture was stirred for a further 2 hours at room temperature
3. 3
   세척The mixture was then washed successively with 1 % strength by weight aqueous solution of sodium hydroxide and water
4. 4
   건조After drying the organic phase over anhydrous sodium sulphate
5. 5
   workup.DISTILLATIONthe toluene was distilled off under reduced pressure

실험 절차

A solution of 21.6 g of 2-bromopropionyl bromide in 30 ml of toluene was added dropwise to a solution of 10.1 g of triethylamine and 16.8 g of 2-benzylthioethanol in 150 ml of toluene at room temperature whilst stirring. After the addition was completed, the reaction mixture was stirred for a further 2 hours at room temperature. The mixture was then washed successively with 1 % strength by weight aqueous solution of sodium hydroxide and water. After drying the organic phase over anhydrous sodium sulphate, the toluene was distilled off under reduced pressure, and the end product of 2-benzylthioethyl 2-bromopropionate was obtained in a yield of 28.8 g as a colorless product.

출처