반응 #93643

ord-812e13182fe14f9bb700a97b0eeb91e4

반응 방정식

C(=NC1CCCCC1)=NC1CCCCC1
DCCI
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O)OCc1ccccc1
Z-Phe-His-OH
CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)C(C)C.[NH-]CCNCCO
H-Leu-Val-Ala 2-(2-hydroxyethylamino)-ethyl amide
On1nnc2ccccc21
HOBt
→
CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)C(C)C.[NH-]CCNCCO
title compound
CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)C(C)C.[NH-]CCNCCO
Z-Phe-His-Leu-Val-Ala 2-(2-hydroxyethylamino)-ethyl amide

반응물

C(=NC1CCCCC1)=NC1CCCCC1
DCCI
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O)OCc1ccccc1
Z-Phe-His-OH
CC(C)C[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)C(C)C.[NH-]CCNCCO
H-Leu-Val-Ala 2-(2-hydroxyethylamino)-ethyl amide
On1nnc2ccccc21
HOBt

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In a manner analogous to that described in Example 1, using as starting materials 88 mg of Z-Phe-His-OH, 60 mg of H-Leu-Val-Ala-2-(2-hydroxyethylamino)-ethyl amide, 31 mg of HOBt and 48 mg of DCCI, the title compound is obtained after flash chromatography (65 g of silica gel 60, 40-63 μm, eluant system B11). Rf (B11)=0.24.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04613676uspto-grants-1986_09