반응 #9356

반응 방정식

NH4Cl

acetyl chloride

MgSO4

KMnO4

5,6,7,8-Tetrahydro-naphthalen-1-ylamine

→

N-(8-oxo-5,6,7,8-tetrahydro-naphthalen-1-yl)-acetamide

용매

CHCl3

NEt3

H2O

acetone

CH2Cl2

반응 조건

후처리

1. 1
   추출The aqueous layer was extracted with CHCl3
2. 2
   기타dried
3. 3
   기타evaporated
4. 4
   기타the amide was used without further purification
5. 5
   추출extracted several times with CHCl3
6. 6
   세척The pooled fractions were washed with brine
7. 7
   건조dried over MgSO4
8. 8
   여과filtered
9. 9
   기타evaporated to dryness
10. 10
    기타The residue was purified by chromatography on SiO2

실험 절차

5,6,7,8-Tetrahydro-naphthalen-1-ylamine (Intermediate J1, commercially available from Aldrich) (5 mL, 35.3 mmol) was dissolved in CH2Cl2 (40 mL) and treated with NEt3 (10 mL) and acetyl chloride (3.8 mL, 53 mmol) at rt for 1 h. The mixture was diluted in CHCl3 and acidified with sat NH4Cl. The aqueous layer was extracted with CHCl3. The organic fractions were combined, dried and evaporated and the amide was used without further purification. The resulting amide (35.3 mmol) in acetone (450 mL) and aqueous MgSO4 (5 g in 28 mL) at 0° C. was treated with KMnO4 (16.8 g, 105 mmol). The mixture was allowed to stir at 0° C. for 2 h. The mixture was diluted with H2O and extracted several times with CHCl3. The pooled fractions were washed with brine and dried over MgSO4, filtered and evaporated to dryness. The residue was purified by chromatography on SiO2 to give N-(8-oxo-5,6,7,8-tetrahydro-naphthalen-1-yl)-acetamide (Intermediate J2) as a yellow oil. (57%, in two 2 steps)

출처