반응 #93543

반응 방정식

β-(p-chlorophenyl)-α-methylene-γ-butyrolactone

benzylmercaptan

→

title compound

수율 81.0%

α-benzylthiomethyl-β-(p-chlorophenyl)-γ-butyrolactone

수율 81.0%

용매

toluene

ethyl ether

반응 조건

후처리

1. 1
   기타After completion of the reaction
2. 2
   세척washed with 10% aqueous sodium hydroxide and saturated saline
3. 3
   건조dried over magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   기타The crude product thus obtained
6. 6
   기타was purified by a column chromatography

실험 절차

To a solution of 700 mg of β-(p-chlorophenyl)-α-methylene-γ-butyrolactone in 10 ml of toluene were added 0.51 ml of benzylmercaptan and one drop of triethylamine and the resulting mixture was kept at room temperature for 6 hours. After completion of the reaction, the reaction mixture was diluted with 100 ml of ethyl ether, washed with 10% aqueous sodium hydroxide and saturated saline, dried over magnesium sulfate and the solvent was distilled off. The crude product thus obtained was purified by a column chromatography to give 900 mg (yield 81%) of the title compound.

출처