반응 #93539

반응 방정식

β-(p-chlorophenyl)-α-methylene-γ-butyrolactone

thiobenzoic acid

→

title compound

수율 75.0%

α-benzoylthiomethyl-β-(p-chlorophenyl)-γ-butyrolactone

수율 75.0%

용매

toluene

ethyl ether

반응 조건

후처리

1. 1
   세척washed with water and saturated saline
2. 2
   건조dried over magnesium sulfate
3. 3
   workup.DISTILLATIONthe solvent was then distilled off
4. 4
   기타The crude product thus obtained
5. 5
   기타was purified by a silica gel column chromatography

실험 절차

To a solution of 600 mg of β-(p-chlorophenyl)-α-methylene-γ-butyrolactone in 10 ml of toluene were added 0.44 ml of thiobenzoic acid and one drop of triethylamine and the reaction was effected at room temperature for 18 hours. The reaction mixture was diluted with 100 ml of ethyl ether, washed with water and saturated saline, dried over magnesium sulfate and the solvent was then distilled off. The crude product thus obtained was purified by a silica gel column chromatography to give 750 mg (yield 75%) of the title compound.

출처