반응 #9352

반응 방정식

ether

2,6-diallyl-4-benzyloxyphenol

methyl α-bromo-4-chlorobenzeneacetate

Cs2CO3

→

methyl α-(2,6-diallyl-4-hydroxyphenoxy)-4-chlorobenzeneacetate

용매

DMF

반응 조건

후처리

1. 1
   세척washed with water and brine
2. 2
   건조dried over MgSO4
3. 3
   여과filtered
4. 4
   농축concentrated in vac
5. 5
   기타Purification by chromatography (SiO2, EtOAc/Hexanes 1:20)

실험 절차

To a solution of 2,6-diallyl-4-benzyloxyphenol (200 mg, 1.0 eq) in DMF (8 mL) were added methyl α-bromo-4-chlorobenzeneacetate (190 mg, 1.0 eq) and Cs2CO3 (285 mg, 1.2 eq). The reaction mixture was stirred at room temperature for 15 h, poured into ether, washed with water and brine, dried over MgSO4, filtered, and concentrated in vac. Purification by chromatography (SiO2, EtOAc/Hexanes 1:20) afforded the desired methyl α-(2,6-diallyl-4-hydroxyphenoxy)-4-chlorobenzeneacetate.

출처