반응 #9351

반응 방정식

4-benzyloxyphenol

allylbromide

K2CO3

acetone

→

desired product

2,6-diallyl-4-benzyloxyphenol

반응 조건

후처리

1. 1
   온도The reaction mixture was refluxed overnight
2. 2
   기타the insoluble materials were removed by filtration
3. 3
   농축The filtrate was concentrated in vac
4. 4
   기타The residue was partitioned between ethyl ether (500 mL) and 2N aqueous NaOH (200 mL)
5. 5
   세척The organic layer was washed with water and brine
6. 6
   건조dried over anhydrous MgSO4
7. 7
   여과filtered
8. 8
   농축concentrated in vac

실험 절차

To a solution of starting 4-benzyloxyphenol (20 g) in acetone (800 mL) were added allylbromide (50 mL) and K2CO3 (60 g). The reaction mixture was refluxed overnight. After cooling to the room temperature, the insoluble materials were removed by filtration. The filtrate was concentrated in vac. The residue was partitioned between ethyl ether (500 mL) and 2N aqueous NaOH (200 mL). The organic layer was washed with water and brine, dried over anhydrous MgSO4, filtered, and concentrated in vac. to give the desired product.

출처