반응 #9347

반응 방정식

HCl

Methyl (4-hydroxyphenyl)acetate

Cs2CO3

2-bromopropane

→

methyl (4-(1-methylethoxy)phenyl)acetate

용매

DMF

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   기타The organic phase was separated
3. 3
   세척washed with water
4. 4
   건조The organic phase was dried over sodium sulfate
5. 5
   기타the solvent was evaporated
6. 6
   기타to give an oil
7. 7
   기타The resulting oil was chromatographed on silica gel

실험 절차

Methyl (4-hydroxyphenyl)acetate (1.0 g, 1.0 eq), Cs2CO3 (2.15 g, 1.1 eq) and 2-bromopropane (0.565 mL. 1.0 eq) were combined in 100 ml DMF at room temperature. The mixture was stirred overnight. The suspension was poured into 50 mL 1 N HCl and extracted with ethyl acetate. The organic phase was separated and washed with water followed by sodium bicarbonate. The organic phase was dried over sodium sulfate and the solvent was evaporated to give an oil. The resulting oil was chromatographed on silica gel using hexanes and ethyl acetate (95:5) to give methyl (4-(1-methylethoxy)phenyl)acetate.

출처