반응 #93469

반응 방정식

2-Chloropropionic acid

benzyl alcohol

ether

Sodium

benzyl alcohol

sodium

→

2-benzyloxypropionic acid

반응 조건

후처리

1. 1
   온도the resulting mixture heated on additional 3 hours
2. 2
   농축Concentration in vacuo

실험 절차

An alternate method for the preparation of ether compounds corresponding to Formula I (R=alkyl, phenylalkyl) follows. Sodium metal (about 12 g) was added cautiously to a stirred cold (ice bath) portion (250 mL) of benzyl alcohol. After most of the sodium metal had dissolved, the reaction was heated to 150° C. 2-Chloropropionic acid (27.2 g, 0.25 mole) was added dropwise in 35 mL of benzyl alcohol and the resulting mixture heated on additional 3 hours. Concentration in vacuo gave crude 2-benzyloxypropionic acid which was used without further purification.

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