반응 #93424

반응 방정식

ethyl acetate

ethyl veratroylacetate

N-methylurea

→

6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione

수율 40.3%

용매

tetralin

반응 조건

후처리

1. 1
   온도After being cooled to 95° C.
2. 2
   여과The precipitate was collected by filtration
3. 3
   세척washed with ethyl acetate

실험 절차

To a solution of ethyl veratroylacetate (8.0 g) in tetralin (24 ml) was added N-methylurea (3.52 g) and the mixture was heated for an hour at 170° C. After being cooled to 95° C., ethyl acetate (33 ml) was added thereto. The precipitate was collected by filtration and washed with ethyl acetate to give 6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione (3.35 g).

출처