반응 #93423

반응 방정식

ethyl nicotinoylacetate

N,N'-dimethylurea

sodium bicarbonate

→

6-(3-pyridyl)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione

수율 35.2%

용매

ethanol

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   세척The extract was washed with brine
3. 3
   건조dried over magnesium sulfate
4. 4
   기타evaporated

실험 절차

To a mixture of ethyl nicotinoylacetate (2.30 g) and N,N'-dimethylurea (1.05 g) were added conc. hydrochloric acid (a few drops) and ethanol (1 ml) and the mixture was stirred at 110°-115° C. for 4 hours under reduced pressure (30 mmHg). After being cooled to ambient temperature, the solution was adjusted to pH 7.0 with an aqueous solution of sodium bicarbonate and extracted with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate and evaporated to give 6-(3-pyridyl)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione (0.91 g).

출처