반응 #93383

반응 방정식

9-(1,3-dihydroxy-2-propoxymethyl)guanine

n-hexadecanoic acid

→

9-(1,3-di-n-hexadecanoyloxy-2-propoxymethyl)guanine

수율 97.6%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   기타The compound was then precipitated in ice water
2. 2
   추출The water was extracted with methylene chloride (3x)
3. 3
   농축The combined methylene chloride extracts were concentrated
4. 4
   기타purified on preparative silica gel plates

실험 절차

To 50 mg of 9-(1,3-dihydroxy-2-propoxymethyl)guanine in 5 ml of N,N-dimethylformamide were added 290 mg dicyclohexycarbodiimide and 300 mg of n-hexadecanoic acid and the solution was stirred at 50° C. for 50 hours. The compound was then precipitated in ice water. The water was extracted with methylene chloride (3x). The combined methylene chloride extracts were concentrated, then purified on preparative silica gel plates developed in 1:9 methanol:methylene chloride to yield 140 mg 9-(1,3-di-n-hexadecanoyloxy-2-propoxymethyl)guanine, m.p. 150°-154° C.

출처