반응 #93378

반응 방정식

hydrogen chloride

1,3-di-O-benzylglycerol

paraformaldehyde

→

1,3-di-O-benzyl-2-O-chloromethylglycerol

용매

1,2-dichloroethane

반응 조건

후처리

1. 1
   건조Next, the solution was dried over magnesium sulfate
2. 2
   여과then filtered
3. 3
   농축concentrated

실험 절차

Dry hydrogen chloride gas was bubbled for 1.5 hours into a solution of 1,3-di-O-benzylglycerol from Preparation I (15 g, 55 mmol) and paraformaldehyde (3.3 g, 110 mmol) in 175 ml of 1,2-dichloroethane at 0° C. The solution was then stored in a stoppered flask for 21 hours at 4° C. Next, the solution was dried over magnesium sulfate with warming to 21° C. then filtered and concentrated to give 17.5 g of 1,3-di-O-benzyl-2-O-chloromethylglycerol.

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