반응 #93370

반응 방정식

alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]amino]ethyl]-3,4,5-trimethoxyphenylacetonitrile

formalin

formic acid

potassium carbonate

→

desired compound

Alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile

용매

water

반응 조건

후처리

1. 1
   온도was refluxed for 1 hour
2. 2
   온도After cooling, to the mixture
3. 3
   추출The solution was extracted with chloroform
4. 4
   세척The extract was washed with water
5. 5
   기타dried
6. 6
   기타evaporated

실험 절차

A mixture of 0.39 g of alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]amino]ethyl]-3,4,5-trimethoxyphenylacetonitrile, 1 ml of 37% formalin, and 1 ml of 90% formic acid was refluxed for 1 hour. After cooling, to the mixture were added water and potassium carbonate to make it alkaline. The solution was extracted with chloroform. The extract was washed with water, dried, and evaporated to give 0.23 g of desired compound as a yellow oil.

출처