반응 #93280

반응 방정식

Compound A

4-(Carboxymethyloxy)benzaldehyde

5,6-diamino-1,3-dipropyluracil

→

6-Amino-1,3-dipropyl-5-(4'-carboxymethyloxybenzylideneamino)uracil

용매

methanol

acetic acid

반응 조건

후처리

1. 1
   기타A representative synthesis of benzylidene adduct
2. 2
   온도After heating 15 minutes
3. 3
   기타the volume was reduced by evaporation until crystallization
4. 4
   workup.ADDITIONEther (40 ml) was added
5. 5
   기타the nearly white solid was collected

실험 절차

A representative synthesis of benzylidene adduct is given. Compound A (1.51 g, 8.37 mmol) was dissolved in a mixture of methanol (35 ml) and acetic acid (5 ml) in a 50 ml boiling flask on a steam bath. To this was added a methanolic solution (60 ml) of freshly synthesized 5,6-diamino-1,3-dipropyluracil. After heating 15 minutes, the volume was reduced by evaporation until crystallization occurred. Ether (40 ml) was added and the nearly white solid was collected. Yield 2.80 g (86%), mp 179°-180° C. Analysis (C19H24N4O5): calc. 58.60% C, 6.21% H, 14.39% N; found 58.72% C, 6.16% H, 14.43% N.

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